PART 1: Write an essay that critically appraises the literature for one of the topics below Word limit: 2500 words Students should consider observational and association studies in humans, as well as explore pathophysiology and mechanisms to develop arguments for the essay. TOPIC: Does body composition influence insulin sensitivity? Papers to start with: Hotamisligil. 2006. Inflammation and metabolic disorders Nature, 444, 860867. https://www.nature.com/articles/nature05485 Mavros et al, 2013. Changes in insulin resistance and HbA1c are related to exercise- mediated changes in body composition in older adults with type 2 diabetes: interim outcomes from the GREAT2DO trial. Diabetes Care, 36(8): 2372-9. https://www.ncbi.nlm.nih.gov/pubmed/23474589 THERE ARE 2 PARTS TO THIS ASSIGNMENT. PLEASE ONLY COMPLETE PART 1 OF THE ASSIGNMENT. The number of sources/references is only a guide. Please use at least 5 references.
