Must also: Needs to cover molecular profile of essential thrombocythaema – looking at the land scape for common mutations in JAK2, CALR and MPL and also the triple negative. Discussing low level burden of these mutations in addition to techniques for picking up. Must discuss hereditary/familial essential thrombocythaemia. Need to cover methylation and epigenetic profiles in essential thrombocythaemia Must discuss the landscape of gene expression profile and what literature says on the matter and role in diagnostic and prognosis
